We typically refer to Advanced Disease as the state of prostate cancer that has grown beyond the prostate and is unlikely to be cured with surgery or radiation alone. After a man experiences PSA progression after surgery or radiation, hormonal therapy is often given at some point, and often for many years. Some men will not require any therapy, however, if their PSA doubling time is quite prolonged. However, many men will continue to progress at some point despite the above hormonal treatments and require more aggressive therapy. This comes in the form of additional second and third-line hormonal therapies, investigational agents (many are in trials right now from new hormonal therapies to prostate cancer vaccines to bone-targeting drugs), and chemotherapy.

Terms to know from this article:


prostate-specific antigen (PSA): A substance produced by the prostate that may be found in an increased amount in the blood of men who have prostate cancer, benign prostatic hyperplasia, or infection or inflammation of the prostate.

Learn More

  • Provenge

    Therapeutic vaccines stimulate the immune system to recognize and fight cancer cells. These treatments are only given in certain centers, and you should discuss.

  • Managing Bone Metastases and Pain

    When prostate cancer cells spread to the bone, it’s known as prostate cancer bone metastases. This can interfere with the bone’s normal health and.