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Prostate Cancer Research

Journal Club

The prostate cancer research field is fast paced. PCF’s Science Department routinely holds scientific discussions with leading cancer researchers to stay abreast of the most recent prostate cancer publications. These meetings keep PCF at the cutting edge of prostate cancer research. This section provides summaries of these “Journal Club” meetings.

Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia Lesion Formation

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

Targeting transcription factor Stat5a/b as a therapeutic strategy for prostate cancer

Cell-surface sensors for real-time probing of cellular environments

Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers

Dihydrotestosterone synthesis bypasses testosterone to drive castration-resistant prostate cancer

GPR30-A potential new therapeutic target for advanced prostate cancer

A novel role for the Vav3 nucleotide exchange factor on androgen receptor coactivation in prostate cancer

Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth

TMPRSS2-ERG-mediated feed-forward regulation of wild type ERG in human prostate cancers

Tumor penetrating peptides for prostate tumor targeting

The role of ETS gene fusions in prostate cancer carcinogenesis: therapeutic implications

Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth

Discovery and Mechanistic Characterization of a Novel Selective Nuclear Androgen Receptor Exporter for the Treatment of Prostate Cancer

Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate

Metabolomic Imaging for Human Prostate Cancer Detection

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

Comparative Effectiveness of Minimally Invasive vs. Open Radical Prostatectomy

B cell-derived lymphotoxin promotes castration-resistant prostate cancer

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

Cytoprotective Mitochondrial Chaperone TRAP-1 As a Novel Molecular Target in Localized and Metastatic Prostate Cancer

Lin-Sca-1+CD49fhigh Stem/Progenitors Are Tumor-Initiating Cells in the Pten-Null Prostate Cancer Model

Germline Structural Variations and Prostate Cancer

CCL2 and IL-6 Promote Survival of Human CD11B+-Peripheral Blood Mononuclear Cells and Induce M2-Type Macrophage Polarization

Heat Shock Protein 90 Inhibitors: New Mode of Therapy to Overcome Endocrine Resistance

miR-21: An Androgen Receptor-Regulated MicroRNA that Promotes Hormone-Dependent and Hormone-Independent Prostate Cancer Growth

An aberrant prostate antigen-specific immune response causes prostatitis in mice and is associated with chronic prostatitis in humans

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

Transforming Human Genome Sequencing

A Small Molecule Polyamine Oxidase Inhibitor Blocks Androgen-Induced Oxidative Stress and Delays Prostate Cancer Progression in the Transgenic Adenocarcinoma of the Mouse Prostate Model

Persistent, biologically meaningful prostate cancer after 1 year of androgen ablation and docetaxel treatment

Synthetic Lethality to Identify Novel Cancer Targets

Angiogenesis Inhibitors: A link between lipid metabolism and prostate cancer

MYC Activity Mitigates Response to Rapamyacin in Prostate Cancer through Eurkaryotic Initiation Factor 4E-Binding Protein 1-Mediated Inhibition of Autophagy

EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

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