Principal Investigator: Geoff Rosenfeld, MD
University of California San Diego

Discovery of Inhibitors of PCa-related Epigenetic Changes

• Created a system to determine the molecular mechanisms that control chromosomal rearrangements (erroneous shuffling of the DNA) which result in gene fusions that are common in prostate cancer.
• Discovered the role of the androgen receptor (a protein that promotes prostate cancer cell growth and survival) and hypoxia (low oxygen levels) in causing the generation of these gene fusions.
• An automated technology (DASL) was developed to discover new medicines that prevent the formation of gene fusions.