Brachytherapy Can Be Successful for High-Risk Prostate Cases, Too
February 9, 2012 -- Although brachytherapy has not been considered a highly effective form of treatment for high-risk prostate cancer, it was shown to reduce prostate cancer–specific mortality (PCSM) compared with external beam radiation therapy (EBRT) alone in a recent large analysis.
Brachytherapy, which involves the precise placement of radiation sources directly at the tumor site, is typically used to treat low- and intermediate-risk prostate cancers. Its use is less common and more controversial in high-risk cases, partially due to early retrospective studies that found this modality to be associated with lower cure rates relative to EBRT, according to a statement issued by Thomas Jefferson University (TJU) in Philadelphia, Pennsylvania. The statement described the findings of the analysis, which were published in the International Journal of Radiation Oncology, Biology, Physics, and noted that poor brachytherapy technique might have contributed to these early unfavorable results.