YI Award Recipients 2014

Huihui Ye, MD:

Harvard Medical School: Beth Israel Deaconess Medical Center

Mentors:

Steven Balk, MD, PhD

Proposal Title:

Investigation of Molecular Mechanisms and Biomarkers of Treatment Resistance in a Randomized, Phase 2 Neoadjuvant Intense Androgen Deprivation Trial in Patients with Localized, Intermediate to High Risk Prostate Cancer

Kosj Yamoah, MD, PhD:

Thomas Jefferson University

Mentors:

Adam Dicker, MD, PhD, Timothy Rebbeck, PhD

Proposal Title:

Identification and Validation of a Biomarker Signature that can Improve Predictability of Aggressive Disease in Men of African Descent with Prostate Cancer

Kamlesh Yadav, PhD :

Icahn School of Medicine at Mount Sinai

Mentors:

Ash Tewari, MD

Proposal Title:

Rational Design of Effective Prostate Cancer Combination Therapies

Kathryn Wilson, ScD:

Harvard School of Public Health

Mentors:

Lorelei Mucci, ScD, Matthew Smith, MD, PhD

Proposal Title:

Bone Metabolism and Bone Metastases in Prostate Cancer

Yu Wang, MD, PhD:

New York University Lagone Medical Center

Mentors:

Susan Logan, PhD, Michael Garabedian, PhD

Proposal Title:

Multivalent Peptidomimetic Conjugates in CRPC Treatment

Li Wang, PhD:

Icahn School of Medicine at Mount Sinai

Mentors:

William Oh, MD and Eric Schadt, PhD

Proposal Title:

Integrative Genomics Study of Immune Signatures in Blood and Tumor Tissue for Prostate Cancer

Sumit Subudhi, MD, PhD:

M. D. Anderson Cancer Center

Mentors:

James Allison, PhD, Padmanee Sharma, MD, PhD

Proposal Title:

Improving Patient Selection for Immune Checkpoint Therapy: Maximizing Benefit and Minimizing Toxicities

Tanya Stoyanova, PhD:

University of California at Los Angeles

Mentors:

Owen Witte, MD

Proposal Title:

Proteolytically Cleaved Receptors as Oncogenes and Therapeutic Targets in Advanced Castration Resistant Prostate Cancer

Matthias Stephan, MD, PhD:

Fred Hutchinson Cancer Research Center

Mentor:

Peter Nelson, MD

Proposal Title:

In Vivo Programming of Prostate Tumor-Specific T cells using Synthetic Nanoparticles

Daniel Spratt, MD:

University of Michigan

Mentors:

Charles Sawyers, MD

Proposal Title:

Androgen Receptor Signaling Post-Radiotherapy: A Novel Non-Invasive Predictive Biomarker for Locally Advanced and Castrate Resistant Prostate Cancer

Jinjun Shi, PhD:

Brigham and Women’s Hospital, Harvard Medical School

Mentors:

Omid Farokhzad, MD, Ulrich von Andrian, MD, PhD

Proposal Title:

mRNA-Based Immuno-Nanotherapeutics for Advanced Prostate Cancer Treatment

Nikolaus Schultz, PhD:

Memorial Sloan-Kettering Cancer Center

Mentors:

Charles Sawyers, MD, Chris Sander, PhD

Proposal Title:

A Genomics-Guided Decision Support System for the Treatment of Prostate Cancer

Anirban Sahu, PhD:

University of Michigan

Mentor:

Arul Chinnaiyan, MD, PhD

Proposal Title:

The Role of Long Noncoding RNA SChLAP1 in Aggressive Prostate Cancer

Brian Olson, PhD:

University of Wisconsin Carbone Cancer Center

Mentors:

Douglas McNeel, MD, PhD, Glenn Liu, MD

Proposal Title:

Targeting Resistance to Androgen Deprivation Therapies using Immunotherapies Targeting the Androgen Receptor

David Olmos, MBBS, MSc, PhD:

Spanish National Cancer Research Centre

Mentors:

Johann de Bono, MD, PhD, Manuel Hidalgo, MD, PhD

Proposal Title:

Integration of Clinical, Molecular and Biological Characteristics to Define an Aggressive Subtype of Prostate Cancer Based on Deficient Homologous Recombination

Todd Morgan, MD:

University of Michigan

Mentors:

Arul Chinnaiyan, MD, PhD, Russell Taichman, DMD, DMSc

Proposal Title:

Defining the Role of the HGF/c-MET Axis as a Mediator of Therapeutic Resistance in Advanced Prostate Cancer

Rohit Malik, PhD, MSc:

Research fellow, University of Michigan

Mentor:

Arul Chinnaiyan, MD, PhD

Proposal Title:

Characterization and Therapeutic Targeting of Androgen Receptor Co-activators in Castration Resistant Prostate Cancer

Everardo Macias, PhD:

Duke University

Mentors:

Stephen Freedland, MD, Jen-Tsan Chi, MD, PhD

Proposal Title:

Kinase Signaling in Prostate Cancer Associated with Obesity

Rajan Kulkarni, MD, PhD:

David Geffen School of Medicine at UCLA

Mentors:

Matthew Rettig, MD, Dino Di Carlo, PhD

Proposal Title:

Utilizing Vortex Chip for Enumeration and Determination of Single-Cell Heterogeneity of Circulating Tumor Cells in Prostate Cancer

Haydn Kissick, PhD:

The Emory Vaccine Center and the Department of Urology, Emory University

Mentors:

Martin Sanda, MD, Rafi Ahmed, PhD

Proposal Title:

Vaccination against Patient Specific Coding Mutations to Treat Prostate Cancer

Charalambos Kaittanis, PhD:

Memorial Sloan-Kettering Cancer Center

Mentors:

Jan Grimm, MD, PhD, Steven M. Larson, MD

Proposal Title:

Overcoming Drug Resistance in Advanced Prostate Cancer with Multifunctional Nanosponges

Neema Jamshidi, MD, PhD:

University of California, Los Angeles

Mentors:

Michael Kuo, MD, Robert Reiter, MD

Proposal Title:

Identifying Gen-Rad-Path (Genomic-Radiology-Pathology) Correlates in Patients with Indolent versus Aggressive Prostate Cancer

Franklin Huang, MD, PhD:

Dana-Farber Cancer Institute

Mentors:

Levi Garraway, MD, PhD

Proposal Title:

Investigating the Genomics of African-American Prostate Cancer

Christopher Heaphy, PhD:

Johns Hopkins University School of Medicine

Mentors:

Alan Meeker, PhD, Angelo De Marzo, PhD, Elizabeth Platz, PhD

Proposal Title:

The Telomere Biomarker for Individualized Prostate Cancer Risk Stratification and Prognostication

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Jeremy Durack, MD, MS:

Memorial Sloan-Kettering Cancer Center

Mentor:

Howard Scher, MD

Proposal Title:

Rapid Spectroscopic Assessment of Targeted Prostate Cancer Biopsy Sufficiency at the Point-of-Care

Marcin Cieslik, PhD:

University of Michigan

Mentor:

Arul Chinnaiyan, MD, PhD

Proposal Title:

Clinical Implications of Expressed Pseudogene Transcripts in Metastatic Castration-Resistant Prostate Cancer

W. Nathaniel Brennen, PhD:

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Mentors:

John Isaacs, PhD, Charles Drake, MD, PhD

Proposal Title:

T cells Engineered to Selectively Deliver a PSA-activated Protoxin to Sites of Advanced Prostate Cancer