We typically refer to Advanced Disease as the state of prostate cancer that has grown beyond the prostate and is unlikely to be cured with surgery or radiation alone. After a man experiences PSA progression after surgery or radiation, hormonal therapy is often given at some point, and often for many years. Some men will not require any therapy, however, if their PSA doubling time is quite prolonged. However, many men will continue to progress at some point despite the above hormonal treatments and require more aggressive therapy. This comes in the form of additional second and third-line hormonal therapies, investigational agents (many are in trials right now from new hormonal therapies to prostate cancer vaccines to bone-targeting drugs), and chemotherapy.
Managing Bone Metastases and Pain
When prostate cancer cells spread to the bone, it’s known as prostate cancer bone metastases (not bone cancer). Once the cells settle in the bone,...
Sipuleucel-T Immunotherapy (Provenge)
In order for the immune system to fight off foreign invaders, it has to learn to recognize what’s normal and what’s not normal. Unfortunately, because...
Terms to know from this article:
Increase in the size of a tumor or spread of cancer in the body.
Treatment that adds, blocks, or removes hormones. For certain conditions (such as diabetes or menopause), hormones are given to adjust low hormone levels. To slow or stop the growth of certain cancers (such as prostate and breast cancer), synthetic hormones or other drugs may be given to block the body's natural hormones. Sometimes surgery is needed to remove the gland that makes hormones. Also called hormone therapy, hormone treatment, or endocrine therapy.
prostate-specific antigen (PSA): A substance produced by the prostate that may be found in an increased amount in the blood of men who have prostate cancer, benign prostatic hyperplasia, or infection or inflammation of the prostate.