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PCF Research Targets Prostate Cancer in African American Men

Each year more than 3 million men in the U.S. battle prostate cancer, and, on average, 1 in 8 men will be diagnosed in their lifetime. However, there are significant racial disparities, particularly for men of African descent. Compared to men of other ethnicities, men of African descent are over 75% more likely to develop prostate cancer and more than twice as likely to die of it. Research indicates a number of disparities for men of African descent including longer wait times between diagnosis and treatment, more side effects and higher costs of care.

At the Prostate Cancer Foundation, we’ve been investing in research that targets these disparities for over 20 years.

We’ve awarded millions of dollars to scientists across the US whose research not only explores how and why prostate cancer behaves differently in men of African descent, but also tests possible solutions. Some of our promising young investigators include:

PCFBrandon Mahal, MD of the Dana-Farber Cancer Institute and Harvard University. Dr. Mahal’s research project will analyze data on more than 15,000 men of African descent with prostate cancer to uncover factors associated with poor prognosis. This information will be used to develop more accurate prediction tools, and will improve treatment selection and outcomes for African American men with prostate cancer.


PCFSalma Kaochar, PhD at Baylor College of Medicine. Dr. Kaochar is looking at specific factors that affect how genes are turned on and off in African American prostate cancer, and that might be new targets for treatments.


PCFMegan McNamara, MD of Duke University. Dr. McNamara will investigate genetic differences between African American and Caucasian prostate cancer in order to better understand biologic contributors to poorer outcomes in African American patients. This project will also determine whether genes can be used to predict response to a specific therapy (abiraterone) and improve treatment selection for patients.

In 2018, PCF partnered in launching the Robert Frederick Smith Center of Precision Oncology in Chicago to aid veterans in the metropolitan area and beyond who are battling prostate cancer. With the generous support of Robert F. Smith, PCF is able to prioritize research proposals with the highest potential benefit to veterans, with a focus on African Americans in the near term.

For patients: What you can do

If you’re a man of African descent with prostate cancer, you, too, can participate in research that aims to uncover how genetic and environmental factors contribute to disease progression. PCF, along with the National Cancer Institute and the National Institute on Minority Health and Health Disparities of the National Institutes of Health, is supporting the RESPOND study, which will help the cancer community understand and address disparities for African American men and their families. Note that this is not a treatment study; your information will be stored securely and analyzed anonymously as part of a large data set. To learn more, visit respondstudy.org.

For all men (and those who care about them)

Take the next steps towards improving your health. Explore below to learn more about what YOU can do to prevent prostate cancer.

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    Prostate Cancer Patient Guide

    Information about contemporary prostate cancer research, treatment, and lifestyle factors all in one consolidated document.
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    Information for African-American Men

    Read about special facts and guidance regarding African-American men and prostate cancer.
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    Determine When to Get Screened

    Learn about when you should start screening for prostate cancer.
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    Prostate Cancer in African-American Men

    African American men are more likely to develop prostate cancer, and more than twice as likely than Caucasian men to die from it.
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