Discovery of Inhibitors of TMPRSS2/ERG Function in Prostate Cancer

About Discovery of Inhibitors of TMPRSS2/ERG Function in Prostate Cancer

Scientists recently discovered that a specific genetic rearrangement in normal prostate cells leads to the production of cancer promoting factors (ETS factors) and prostate cancer. It is presumed that discovery of medications that block the activity of ETS factors will arrest the growth of prostate cancer. Dr. Golub will apply state-of-the-art genetic biotechnologies in a significant drug discovery effort to target ETS factors produced by prostate cancer cells. Collaborators at the Broad Institute of Harvard and MIT will work with biologists and oncologists at the Dana-Farber Cancer Institute and Harvard Medical School to evaluate ETS factor inhibitors discovered in this work and ultimately develop an experimental medication for prostate cancer patients.

Lead Investigator:

Dr. Levi A. Garraway, Dana-Farber Cancer Institute, Broad Institute; Dr. Todd R. Golub, Broad Institute of Harvard and MIT; Dr. William C. Hahn, Dana-Farber Cancer Institute, Broad Institute.