Sulforaphane and Prostate Cancer Interception

About Sulforaphane and Prostate Cancer Interception

What this means to patients:Consumption of sulforaphane in broccoli may provide validated intervention to prevent progression of prostate cancer in active surveillance patients, alleviating overtreatment.

Synopsis: Cellular oxidative stress can result from an imbalance in cellular processes and its inability to readily eliminate toxic intermediates of normal cellular reactions, and may cause disruptive mutations, leading to metabolic transformation and cancer. Certain dietary factors, such as red meat and dairy products, can enhance oxidative stress. Other dietary factors, such as sulforaphane obtained from broccoli, can reduce oxidative stress and prevent or reverse metabolic deregulation. Dr. Mithen and his team propose to undertake a human intervention study to test the hypothesis that sulforaphane can alter the metabolism and gene expression of at-risk, non-cancerous tissues in active surveillance patients in a manner that would reduce the probability of the emergence of aggressive clones.

The study will examine global gene expression and metabolite profile from prostate biopsies before and after a 12-month intervention, combined with analyses of metabolites in plasma and urine from active surveillance patients. The study will provide evidence for the role of sulforaphane in metabolic transformation and will identify the underlying mechanisms by which sulforaphane can reduce the risk of aggressive prostate cancer.

Richard Mithen, PhD

Institute of Food Research

Co-investigators:

Colin Cooper, PhD, University of East Anglia and Maria Traka, PhD, Institute of Food Research