Talking with your doctor.
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Why be proactive?
It’s a good idea to proactively ask about somatic and germline genetic testing during your appointments. Most doctors strive to provide excellent care, but they may not always know the latest testing recommendations—especially as research advances and new treatments become available. Taking a proactive approach and asking your doctor about somatic and germline genetic testing will help you receive the most current and personalized care.

Here are some questions you can ask your doctor:
- Have my healthy cells and my tumor cells been tested for gene alterations that affect cancer treatment response, prognosis, risk, and so on? If so, which tests were done?
- What samples were taken (tumor tissue, blood, saliva)?
- Were any gene alterations or other changes found? If yes, which ones?
- How do the results affect my treatment options?
- How can I get a copy of my test reports?
- Am I eligible for any clinical trials based on my test results?
- Should I be re-tested if the results were unclear or if my disease has progressed?
- If I have not been tested, can I be tested now?
- Should I schedule an appointment with a genetic counselor?
- Should my family members consider germline genetic testing? If yes, who can advise them about this and help them get tested if they want to?
How much do these tests cost? Does insurance cover them?
Medicare and most private insurance plans cover somatic and germline genetic testing for patients with advanced prostate cancer. Out-of-pocket costs can be up to $250 for germline genetic tests, while somatic testing costs more (price varies). If you need help paying for testing, financial assistance or payment plans may be available. Ask your doctor or care team for guidance. Many testing companies also offer free phone and telemedicine services to help you learn more about tests and costs.
It’s a good idea to ask about somatic and germline genetic testing during your appointments. Being proactive can help you get the best possible care.