Beatrice Knudsen, MD, PhD
About Beatrice Knudsen, MD, PhD
Biomarkers of Response to Treatment with XL184 in the Bone
XL184 (caboxantanib) is a new experimental medication for metastatic prostate cancer with promising clinical results. To more effectively administer XL184 to patients with metastatic prostate cancer, Dr. Knudsen seeks to define the precise anti-cancer mechanism of action. She has assembled a team at Cedars-Sinai in Los Angeles and University of Washington/Fred Hutchinson Cancer Institute in Seattle to study the effects of XL184 in patient biopsies and will investigate the mechanism of action of this encouraging agent as a biomarker for response in patients.
Potential patient benefit: An understanding of the mechanism of action of XL184 will accelerate the clinical development of this very encouraging agent by providing investigators with laboratory and imaging biomarkers of response.
The Susan and James Blair-PCF Creativity Award
Medical Director of Biorepository and Translational Pathology
Cedars-Sinai Medical Center