Peter Nelson, MD
About Peter Nelson, MD
Targeting Therapy-Induced Resistance Mechanisms in the Prostate Tumor Microenvironment
Dr. Nelson postulates that chemotherapy resistance originates in the tumor microenvironment in response to stress caused by chemotherapy. He has discovered that tumor cell repopulation accelerates during the intervals between courses of treatment causing resistance to further chemotherapy. This proposal seeks to understand the series of events occurring in the tumor microenvironment resulting in resistance to chemotherapy.
Potential patient benefit: An understanding of the series of biologically programmed events in the tumor microenvironment that cause chemotherapy resistance will lead to resensitization strategies and improved efficacy of chemotherapy, the mainstay treatment for metastatic prostate cancer.
Fred Hutchinson Cancer Research Center