2025 Gift of Donald L. McMichael and Frank L. Yangl, Jr. Estates – PCF Challenge Award
Targeting AR by Proximity Induced Epigenetic Silencing (PIES) to Overcome Castration Resistance
Principal Investigators: Steven Balk, MD, PhD (Harvard: Beth Israel Deaconess Medical Center (BIDMC)), Wenyi Wei, PhD, (Harvard: Beth Israel Deaconess Medical Center (BIDMC)), Jian Jin, PhD (Icahn School of Medicine at Mount Sinai Hospital)
Co-Investigator: Yan Xiong, PhD (Icahn School of Medicine at Mount Sinai Hospital)
Young Investigators: Larysa Poluben, PhD (Harvard: Beth Israel Deaconess Medical Center (BIDMC)), Zhen Wang, PhD (Harvard: Beth Israel Deaconess Medical Center (BIDMC)), Dingpeng Zhang, PhD (Harvard: Beth Israel Deaconess Medical Center (BIDMC))
2025 PCF Challenge Award
Selective Proximity Targeting of AR and p300/CBP as a Therapeutic Strategy in Prostate Cancer
Principal Investigators: Arul Chinnaiyan, MD, PhD (University of Michigan), Shaomeng Wang, PhD (University of Michigan), YuanYuan Qiao, PhD (University of Michigan)
Co-Investigator: Mi Wang, PhD (University of Michigan)
Young Investigators: Jie Luo, PhD (University of Michigan), Jianzhang Yang, PhD (University of Michigan)
2025 Michael and Lori Milken Family Foundation – PCF Challenge Award
Theranostic Targeting of a Tumor-Specific Cleaved CDCP1 Epitope in Prostate Cancer
Principal Investigators: Jonathan Chou, MD, PhD (University of California, San Francisco), Jim Wells, PhD (University of California, San Francisco), Michael Evans, PhD (University of California, San Francisco), Rahul Aggarwal, MD (University of California, San Francisco), Joshua Lang, MD (University of Wisconsin)
Co-Investigator: Kevin Leung, PhD (University of California, San Francisco)
Young Investigators: Carissa Chu, MD (University of California, San Francisco), Apurva Pandey, PhD (University of California, San Francisco)
2025 Michael and Lori Milken Family Foundation – PCF Challenge Award
PARP Inhibition with SABR for High-Risk Mutation Oligometastatic Castration-Sensitive Prostate Cancer
Principal Investigators: Matthew Deek, MD (Rutgers Biomedical and Health Sciences), Phuoc Tran, MD, PhD (The University of Texas MD Anderson Cancer Center), Shuang Zhao, MD, MSc (University of Wisconsin), Ke Nie, MD (Rutgers Biomedical and Health Sciences)
2025 PCF Challenge Award
Predicting Off-Target Resistance to Androgen Receptor Signaling Inhibitors from Histology Slides using Foundation Models
Principal Investigators: Ekta Khurana, PhD (Weill Cornell Medicine), Iman Hajirasouliha, PhD (Weill Cornell Medicine), Yu Chen, MD, PhD (Memorial Sloan Kettering Cancer Center), Anuradha Gopalan, MD (Memorial Sloan Kettering Cancer Center)
Co-Investigators: Wassim Abida, MD, PhD (Memorial Sloan Kettering Cancer Center), Francisco Sanchez Vega, PhD (Memorial Sloan Kettering Cancer Center), Brian Robinson, MD (Weill Cornell Medicine)
Young Investigator: Elvire Roblin, PhD (Weill Cornell Medicine)