2025 AIRA Matrix – PCF Special Challenge Award
Testing Deep Learning Algorithms for Prognostication and Prediction in Prostate Cancer: A Clinical Validation Study
Principal Investigators: Tamara Lotan, MD (Johns Hopkins University), Angelo De Marzo, MD, PhD (Johns Hopkins University), Alex Baras, MD, PhD (Johns Hopkins University)
2025 PCF Challenge Award
Targeting Extrachromosomal DNA in Prostate Cancer: A Novel Approach to Overcome Treatment Resistance
Principal Investigators: Rana McKay, MD (University of California, San Diego), Christina A. Jamieson, PhD (University of California, San Diego)
Co-Investigators: Ludmil B. Alexandrov, PhD (University of California, San Diego), Jingjing Zou, PhD (University of California, San Diego), Vineet Bafna, PhD (University of California, San Diego)
Young Investigator: Yu-Wei Chen, MD (University of California, San Diego)
2025 The John Black Charitable Foundation – PCF Challenge Award
Detecting Molecular and Histopathological Correlates of Whole Genome Duplication in High-Risk Prostate Cancer
Principal Investigators: Ian Mills, PhD (University of Oxford), Srinivasa Rao Rao, PhD, MBBS (University of Oxford)
Co-Investigators: Freddie Hamdy, MD, PhD (University of Oxford), Jens Rittscher, PhD (University of Oxford), Clare Verrill, MD (University of Oxford), Dan Woodcock, PhD (University of Oxford), Roman Fischer, PhD (University of Oxford), Simon Davis, PhD (University of Oxford), Gerhardt Attard, MD, PhD (University College London (UCL) Cancer Institute), Peter Nelson, MD (University of Washington), Claire Edwards, PhD (University of Oxford)
Young Investigator: Mazlina Ismail, PhD (University College London (UCL) Cancer Institute)
Collaborators: Kenneth Pienta, MD (Johns Hopkins University), Willem Bonnaffe PhD (University of Oxford)
2025 Donnini-Rudolph Family Foundation – PCF Challenge Award
AI-driven Omics-Mapping of Key Factors for Long-term Remission in mPCa and Development of Novel Adoptive Cell Immunotherapy
Principal Investigators: Ping Mu, PhD (Yale University), Adam Sharp, MD, PhD (Institute of Cancer Research (ICR)), Isaac Kim, MD, PhD (Yale University), Sidi Chen, PhD (Yale University)
Co-Investigators: Michael Leapman, MD (Yale University), Shrikant Mane, PhD (Yale University), Su Deng, PhD (Yale University), Lei Peng, PhD (Yale University)
Young Investigators: Siyuan Cheng, PhD (Yale University), Chuanpeng Dong, PhD (Yale University)
Collaborators: Adebowale Adeniran, MD (Yale University), Tao Wang, PhD (The University of Texas MD Anderson Cancer Center)
2025 PCF Challenge Award
Multifactorial Antigen-Presenting Gamma-Delta T cells Targeting Cancer and Viral Antigens for the Treatment of mCRPC
Principal Investigators: Saul Priceman, PhD (University of Southern California), Branden Moriarity, PhD (University of Minnesota), John Lee, MD, PhD (University of California, Los Angeles), Beau Webber, PhD (University of Minnesota)
Young Investigator: Joseph Skeate, PhD (University of Minnesota)