July 6, 2020 1:00 PM PST – The Prostate Cancer Foundation (PCF) is convening a Global Knowledge Exchange on Oligometastatic Prostate Cancer.
The clinical entity of “oligometastatic cancer” has been suggested as an intermediate state between localized disease and widespread metastases. Newer imaging modalities for prostate cancer including PSMA PET have resulted in an increasing volume of newly diagnosed patients with low-volume metastatic disease. Coupled with the availability of newer agents that more effectively treat metastases, there is a move to treat such patients more aggressively, including surgery or radiation for the primary tumor, with the goal of slowing disease trajectory or perhaps curing a subset of them. Many questions remain, including the optimal definition of “oligometastatic”, sequencing of therapy, duration of systemic therapy, and defining the best clinical trial endpoints. This webinar is intended to have a panel of experts address these issues and point the way forward. More details here.
June 10, 2020 1:00 PM PST – Global PCF Knowledge Exchange on PSMA Theranostics. More details here.
June 3, 2020 1:00 PM PST – Prostate Cancer Foundation Global Knowledge Exchange #2 on COVID19 & TMPRSS2
There has been a recent and productive shift by many cancer scientists to work on solutions for the SARS-CoV-2 pandemic. The Prostate Cancer Foundation (PCF) is convening a Global Knowledge Exchange on ongoing and emerging clinical trials on agents targeting TMPRSS2 in COVID-19. This is a follow up to our previous Global Knowledge Exchange on TMPRSS2 biology and inhibition on May 13, 2020.
This 1.5 hour webinar will be held on June 3, 2020 at 1PM PT | 4PM ET | 9PM London | 10PM Berlin / June 4 at 6AM Melbourne.
Dr. Howard Soule (PCF)
Dr. Charles Ryan (University of Minnesota): Overview on TMRPSS2 biology & rationale for therapeutic targeting in COVID-19.
Dr. William Dahut (National Cancer Institute): Role of NCI in COVID-19 research
Dr. Joseph Vinetz (Yale University): Camostat vs. Placebo in COVID-19 Outpatients. (NCT04353284)
Dr. Ole Søgaard (Aarhus University, Denmark): Camostat vs. Placebo in hospitalized patients and outpatients with COVID-19 Infection (CamoCO-19). (NCT04321096)
Dr. Alan Bryce (Mayo Clinic Arizona): Randomized Trial of SOC with Camostat or Placebo in Hospitalized patients with COVID-19.
Dr. Nicholas Nickols (University of California Los Angeles; VA Greater Los Angeles Healthcare System): Hormonal intervention for Veterans with COVID-19 requiring hospitalization (HITCH). (NCT04397718)
Dr. Andreas Josefsson (Umeå University Hospital, Sweden): Randomized trial: SOC +/- enzalutamide in patients hospitalized for COVID-19.
Dr. Silke Gillessen (Istituto Oncologico della Svizzera Italiana, Switzerland): Randomized trial: SOC +/- enzalutamide in patients positive for SARS-CoV2 at time of first symptoms
Dr. Catherine Handy Marshall (Johns Hopkins University School of Medicine): A phase II Trial to Promote Recovery from COVID-19 with ivermectin or endocrine therapy (RECOVER). (NCT04374279)
Dr. William Oh (Icahn School of Medicine at Mount Sinai): COVID-19 and ADT: A Case Control Series at Mount Sinai.
May 13, 2020 – Prostate Cancer Foundation Global Knowledge Exchange on COVID19 & TMPRSS2
There has been a recent and productive shift by many cancer scientists to work on solutions for the coronavirus pandemic.
Recent studies have demonstrated that the androgen-regulated protease TMPRSS2 is required for SARS-CoV2 entry into host cells. This suggests that inhibiting the TMPRSS2 protease or its expression may be an effective treatment for COVID19.
This will be the first of a 2-part series by the Prostate Cancer Foundation (PCF) Global Knowledge Exchange on this topic. In this first webinar, the speakers will briefly discuss their recent research on TMPRSS2 biology, treatment ideas for SARS-CoV2 infection, followed by discussion / Q & A.
A second webinar at a later date will address emerging clinical trials on TMPRSS2 inhibition in patients with SARS-CoV-2 infection.
Dr. Christina Jamieson (University of California, San Diego)
Dr. Arul Chinnaiyan (University of Michigan)
Dr. Nima Sharifi (Cleveland Clinic)
Dr. Carlos Cordon-Cardo (Mount Sinai School of Medicine)
Dr. Andrea Alimonti (Università della Svizzera Italiana, Switzerland)
Moderated by: Dr. Howard Soule (Prostate Cancer Foundation)
April 15, 2020 – Global Prostate Cancer Foundation (PCF) Journal Club #ProPSMA Study
Speaker: Prof. Michael Hofman, Peter MacCallum Cancer Centre, Australia
Title: Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multi-centre study
Talk followed by interactive Q&A. Panel includes, ProPSMA investigators:
Prof Declan Murphy, Urology, Peter MacCallum Cancer Centre, Melbourne, Australia
Prof Scott WIlliams, Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia
And special guests:
Dr Jeremie Calais, UCLA, USA
Prof Kirsten Greene, Urology, UVAHealth
Professor Caroline Moore, University College London, UK