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Salvage MR-guided High-Dose-Rate Brachytherapy for Prostate Bed Recurrence After Radiotherapy in the PSMA PET Scan Era

About This Trial

  • This clinical trial is studying a targeted internal radiation treatment, guided by detailed MRI scans, for patients whose prostate cancer has returned after previous radiation therapy.
  • It is designed for adults who have rising PSA levels and cancer that has come back only in the area where the prostate used to be.
  • To be eligible, your cancer must not have spread to distant parts of your body, and you must not have had severe bowel or urinary complications from prior radiation.
  • Before considering this study, patients should know that it involves a procedure to deliver radiation directly inside the body as well as multiple MRI scans.

More Information

  • This is an interventional, single-centre, single-arm, non-randomized, prospective, feasibility trial investigating salvage MR-guided High-Dose-Rate brachytherapy for prostate bed recurrence after postoperative radiotherapy.

Who Can Enroll

  • Age Range: 18 years and older
  • Gender: Male
  • Who This Trial is For: This clinical trial is studying a targeted internal radiation treatment, guided by detailed MRI scans, for patients whose prostate cancer has returned after previous radiation therapy.

Study Details

  • Start Date: August 8, 2024
  • Lead Sponsor: University Health Network, Toronto
Full Eligibility Criteria

Inclusion Criteria

  • Patients who received previous RT to the prostate bed +/- pelvic nodal regions
  • Prostate-bed recurrence identified by biopsy and/or MRI and/or PSMA-PET scan
  • At least two continuous PSA elevations post RT and PSA above 0.2 ng/dl
  • With or without ADT PSA doubling time from nadir greater than 6 months
  • ECOG 0-2
  • Age greater than 18 years

Exclusion Criteria

  • Radiological (e.g. PSMA PET, CT, MRI or bone scan) evidence of or distant metastases
  • History of ≥G3 gastrointestinal (GI) and genitourinary (GU) toxicities following RT
  • Any contraindications to MR and/or brachytherapy

Treatments

  • Radiation: High Dose Rate Brachytherapy
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