YI Awards

Antonina Mitrofanova, PhD:

Rutgers, The State University of New Jersey

Mentor:

Michael Shen, PhD

Project Title:

A systems biology approach to identify and evaluate novel drug targets for aggressive prostate cancer

Rohit Mehra, MD:

University of Michigan School of Medicine

Mentor:

Arul Chinnaiyan, MD, PhD

Project Title:

Clinicopathological characterization of novel lncRNAs in prostate cancer risk stratification

PCF Awards:

2013 PCF Young Investigator Award

Marcin Cieslik, PhD:

University of Michigan

Mentor:

Arul Chinnaiyan, MD, PhD

Proposal Title:

Clinical Implications of Expressed Pseudogene Transcripts in Metastatic Castration-Resistant Prostate Cancer

Theodoros Karantanos, MD:

MD Anderson Cancer Center

Mentors:

Timothy Thompson, PhD and Christopher Logothetis, MD

Project Title:

The role of aerobic glycolysis in the development of castrate resistant prostate cancer

W. Nathaniel Brennen, PhD:

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Mentors:

John Isaacs, PhD, Charles Drake, MD, PhD

Proposal Title:

T cells Engineered to Selectively Deliver a PSA-activated Protoxin to Sites of Advanced Prostate Cancer

Hao Hu, MD, MBBS:

People’s Hospital, Peking University

Mentors:

Kexin Xu, MD, MBBS and Xiaofeng Wang, MBBS

Project Title:

EMI1 and its role in prostate cancer initiation and progression.

Andrew Armstrong, MD, ScM:

Duke University – Durham, NC

Vivek Arora, MD, PhD:

Washington University

Mentor:

Charles Sawyers, MD

Project Title:

Defining strategies to overcome enzalutamide (Xtandi) resistance

Jennifer Bishop, PhD:

University of British Columbia

Mentors:

Martin Gleave, MD and Amina Zoubeidi, PhD

Project Title:

Regulation of cell plasticity by the androgen receptor: A novel mechanism of enzalutamide (Xtandi) resistance

Irfan Asangani, PhD:

University of Michigan

Mentor:

Arul Chinnaiyan, MD, PhD

Project Title:

Characterization and therapeutic targeting of MMSET in prostate cancer

Qi Cao, PhD:

Houston Methodist Research Institute

Mentor:

Arul Chinnaiyan, MD, PhD

Project Title:

A novel role for Polycomb Group proteins in androgen signaling and prostate cancer

Charles Chan, PhD:

Stanford University School of Medicine

Mentors:

Irving Weissman, MD and Michael Longaker, MD

Project Title:

Identification and therapeutic targeting of cancer stem cell niche interactions in metastatic prostate bone marrow disease

Chia-Yi Chu, PhD:

Cedars-Sinai Medical Center

Mentor:

Leland Chung, PhD

Project Title:

Metastasis-initiating cells (MICs) as predictors of lethal progression of human prostate cancer

Michael Evans, PhD:

University of California, San Francisco

Mentors:

Charles Sawyers, MD and Jason Lewis, PhD

Project Title:

Exploiting the genetics of advanced prostate cancer for tumor detection and therapy with transferrin-based radionuclides

Jason A. Efstathiou, MD, DPhil:

Massachusetts General Hospital

Mentor:

Matthew R. Smith, MD, PhD

Project Title:

Predictors of Response and Failure to Radiotherapy for Prostate Cancer in a Randomized Trial

Geraldine Gueron, PhD:

Iquibicen-Conicet (Argentina)

Mentor:

Elba Vazquez, PhD

Project Title:

Proteome-base biomarkers in prostate cancer: protein profiling using mass spectrometry, bioinformatics based approach and tissue microarray technology

Mentors:

Philip Kantoff, MD and Christopher Sweeney, MBBS

Project Title:

Clinical exploration of innovative targeted and immune modulating therapies in prostate cancer

Emmanuel Antonarakis, MD:

Johns Hopkins University School of Medicine

Mentors:

Michael Carducci, MD and Jun Luo, PhD

Project Title:

Understanding mechanisms of response and resistance to abiraterone (Zytiga) and enzalutamide (Xtandi) in men with metastatic castration-resistant prostate cancer, by interrogation of tumor biopsies for androgen receptor splice variants.

Syed Adnan Ali, MD:

Mount Sinai School of Medicine

Mentor:

Ashutosh Tewari, MD

Project Title:

Intratumor Heterogeneity (ITH) in Prostate Cancer

Institution:

University of Michigan

Mentors:

Arul Chinnaiyan, MD, PhD; Felix Feng, MD

Proposal Title:

Investigating Long Noncoding RNAs in Aggressive Prostate Cancer

Rendong Yang, PhD:

University of Minnesota

Mentor:

Scott Dehm, PhD

Proposal Title:

Delineating Coding and Regulatory Indels in Prostate Cancer

Adam Sowalsky, PhD:

National Cancer Institute

Mentors:

Kathleen Kelly, PhD; William Dahut, MD

Proposal Title:

Investigations into the Mechanisms of Resistance to Enzalutamide in CRPC

Prasanna Sooriakumaran, MBBS, PhD:

University of Oxford

Mentor:

Freddie C. Hamdy, MD

Proposal Title:

Improving Quality of Care for Men with Skeletal Metastases from Prostate Cancer: Defining the Burden-of-Treatment and its Management, and Developing Models to Predict Quality-of-Life

Shabnam Shalapour, PhD:

University of California, San Diego

Mentor:

Michael Karin, PhD

Proposal Title:

Development of Immunosuppressive Plasmocytes that Interfere with T-Cell-Dependent Immunogenic Chemotherapy in Prostate Cancer

Saul Priceman, PhD:

City of Hope National Medical Center

Mentor:

Stephen Forman, MD

Proposal Title:

Targeting Metastatic Prostate Cancer with PSA-Specific Chimeric Antigen Receptor-Engineered T-Cells

Sean McGuire, MD, PhD:

Baylor College of Medicine

Mentor:

Bert O’Malley, MD

Proposal Title:

Targeting the Mitochondrial Pyruvate Carrier in Castration- Resistant Prostate Cancer

Ravi Madan, MD:

National Cancer Institute

Mentor:

James Gulley, MD, PhD

Proposal Title:

Using A Therapeutic Cancer Vaccine to Enhance Anti-PD-1 Therapy Prior to Prostatectomy

Zhenfei Li, PhD:

Cleveland Clinic Foundation

Mentors:

Nima Sharifi, MD; Eric Klein, MD

Proposal Title:

A Novel Abiraterone Metabolite as a Predictive Biomarker for Clinical Response to Abiraterone

John Kyung Lee, MD:

University of Washington

Mentor:

Owen Witte, MD

Proposal Title:

Therapeutic Targeting of N-Myc-Driven Human Small Cell Neuroendocrine Prostate Cancer

Vishal Kothari, PhD:

University of Michigan

Mentors:

Arul Chinnaiyan, MD, PhD; Felix Feng, MD

Proposal Title:

Investigating DNAPK as a Therapeutic Target and a Prognostic Biomarker in Castration-Resistant Prostate Cancer

Won Kim, MD:

University of California, San Francisco

Mentors:

Charles Ryan, MD; Eric Small, MD

Proposal Title:

Dissecting Variant Androgen Signaling Phenotypes to Guide Treatment Selection in Abiraterone Acetate and Enzalutamide-Resistant Prostate Cancer

Joseph Ippolito, MD, PhD:

Washington University School of Medicine in St. Louis

Mentors:

Jeffrey Arbeit, MD; Farrokh Dehdashti, MD

Proposal Title:

Characterizing and Imaging Metabolic Symbiosis in Castrate- Resistant Prostate Cancer

Amanda Hargrove, PhD:

Duke University

Mentors:

Hashim Al-Hashimi, PhD; Peter Dervan, PhD

Proposal Title:

Targeting the lncRNA SChLAP1 in Aggressive Prostate Cancer by the Assembly of Multivalent Small Molecule Inhibitor

Justin Drake, PhD:

Rutgers University Cancer Institute of New Jersey

Mentor:

Robert DiPaola, MD

Proposal Title:

Elucidating Kinase Activation Pathways in Advanced Prostate Cancer

Heather Cheng, MD, PhD:

University of Washington

Mentor:

Peter Nelson, MD

Proposal Title:

Identifying High-Penetrance Prostate Cancer Risk Genes: Leveraging Families for Next Generation Discovery and Prevention

Institution:

Memorial Sloan Kettering Cancer Center

Institution:

Weill Cornell Medicine

Discipline:

Urology