COsegregation of VARiants in Panel of Genes
Study of Family COsegregation of Nucleotide VARiants in the Panel of Genes to Validate Their Use in Genetic Counseling
About This Trial
- This study looks at how specific, uncertain gene changes run in families to better understand hereditary cancer risks.
- It is open to adults who had genetic testing showing a particular gene change of interest, as well as their adult relatives with or without cancer.
- Rather than testing a new medication, researchers will examine genetic information across family members to clarify whether a specific gene change increases the risk of cancer.
- The goal is to provide clearer genetic counseling and help doctors recommend the most effective cancer screening and preventive care options for you and your family.
More Information
- The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling.
- The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.
Who Can Enroll
- Age Range: 18 years and older
- Gender: All
- Who This Trial is For: This study looks at how specific, uncertain gene changes run in families to better understand hereditary cancer risks.
Study Details
- Start Date: July 2, 2012
- Lead Sponsor: Institut Curie
Full Eligibility Criteria
Inclusion Criteria
Index cases:
- A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned.
- Age ≥ 18 years.
- Signed written inform consent "index case" Related parties:
- Any relative of an index case with cancer
- Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case
- For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care.
- Age ≥ 18 years
- Information and signature of the informed consent "selected relatives"
Exclusion Criteria
- Minors
- Persons deprived of liberty or under guardianship (including curators).
- Absence of signed written inform consent
Treatments
- Genetic: salivary kit