About Geraldine Gueron
- Proteomics is the study of proteins in a cell and their interactions with each other.
- The overall goal of this research is to use proteomics for the identification of predictive prostate cancer disease biomarkers.
- Dr. Gueron has demonstrated that a protein designated Heme Oxygenase-1 (HO-1) is involved in prostate cancer etiology and that it directly interacts with other cancer-causing proteins involved in cell signaling.
- Studying the interaction of HO-1 and other cell signaling molecules is significant because it is believed to regulate the engine of prostate cancer – the androgen receptor.
What this means for patients: This novel targeted proteomics study may do two things: 1) develop a laboratory test that will predict the presence of potentially lethal prostate cancer and 2) discover targets for the treatment of advanced metastatic prostate cancer.
2013 Stanley Zax-PCF Young Investigator
Geraldine Gueron, PhD
Elba Vazquez, PhD
Proteome-base biomarkers in prostate cancer: protein profiling using mass spectrometry, bioinformatics based approach and tissue microarray technology