About Daniel Thorek
- Treatment of advanced, metastatic prostate cancer, although greatly improved with new treatments, still represents an unmet medical need.
- Prostate cancer expresses a molecule called hK2 (human Kallikrein 2), an enzyme similar to PSA.
- Dr. Thorek proposes to direct lethal, alpha-emitting isotope to prostate cancer tumors with a protein that targets hK2. This radioisotope will be internalized by the tumor cell and will result in its total destruction.
What this means for patients: The specific delivery of a radioisotope to prostate tumors represents a new therapy for advanced, metastatic prostate cancer.
2013 Steve Wynn-PCF Young Investigator
Daniel Thorek, PhD
Johns Hopkins University
David Scheinberg, MD, PhD and Steve Larson, MD
Alpha-particle therapy by 225Actinium-labeled prostate kallikrein-specific antibody to eradicate advanced disease