Joseph Ippolito

Joseph Ippolito
About Joseph Ippolito
  • Metabolic oxidative phosphorylation (OXPHOS) is a biochemical process that may lead to therapy resistance and tumor recurrence in men with prostate cancer. Characterizing the metabolism of treatment-resistant prostate cancer (CRPC) tumors will validate potential use of OXPHOS for diagnosis, imaging, and treatment in men suffering from the disease.
  • Dr. Joseph Ippolito will model metabolism in CRPC cells to evaluate the effects of OXPHOS on tumor growth and survival and determine if inhibiting OXPHOS will decrease tumor burden.
  • Another challenge to managing CRPC is the present lack of precise imaging techniques to measure tumor burden in metastatic prostate cancer. Dr. Ippolito will use a mouse model of CRPC treated with OXPHOS inhibitors to test the feasibility of imaging decreased tumor metabolism.
  • If successful, Dr. Ippolito’s research will lead to development of a novel medication, as well as innovative tools for identifying more lethal types of prostate cancer during the crucial early phase of a man’s disease and monitoring the effects of treatment on CRPC tumors.

What this means for patients: Characterizing the metabolic activity of CRPC cells will lay the groundwork for a new paradigm of research targeting prostate cancer. This research may lead to development of new treatments that improve outcome for patients.


2015 Victoria & Vinny Smith, Eustace Wolfington,
and Ali & Joe Torre–PCF Young Investigator

Joseph Ippolito, MD, PhD

Washington University School of Medicine in St. Louis


Jeffrey Arbeit, MD; Farrokh Dehdashti, MD

Proposal Title

Characterizing and Imaging Metabolic Symbiosis in Castrate- Resistant Prostate Cancer