About Kosj Yamoah
The risk of developing and dying from prostate cancer is higher in men of African descent. A genomic classifier test has been developed to identify men with prostate cancers that have increased aggressive and metastatic potential. This test was developed using men of European descent and its relevance in men of other ethnic backgrounds is unknown.
Dr. Kosj Yamoah will assess prostate cancer gene expression profiles in men of African descent to identify biomarkers of increased risk for aggressive disease.
If successful, this project will identify biomarkers that detect men of African descent with more aggressive tumors to direct treatment regimens and lead to further insight in prostate cancer biology.
What this means for patients: A critical factor in patient management is the successful stratification of patients who need aggressive treatment from patients for whom watchful waiting is appropriate. This project will identify biomarkers that differentiate indolent from aggressive tumors in men of African descent to guide selection of appropriate treatment strategies.
2014 J. Eustace Wolfington-PCF Young Investigator
Kosj Yamoah, MD, PhD
Thomas Jefferson University
Adam Dicker, MD, PhD, Timothy Rebbeck, PhD
Identification and Validation of a Biomarker Signature that can Improve Predictability of Aggressive Disease in Men of African Descent with Prostate Cancer