Muneesh Tewari, MD, PhD
About Muneesh Tewari, MD, PhD
Exosomal RNAs as Serum Prostate Cancer Biomarkers—Personalized Treatment and Better Prognostic Indicators May Become Reality Through MicroRNA Tumor Profiling
MicroRNAs, small RNA molecules that regulate gene expression, have been found to circulate in blood within lipid membrane-encased particles (exosomes) that are secreted from and blebbed off of cancer cells. These molecules which are “spit” into the blood stream appear cancer-specific and hold great promise for molecular profiling of tumors. This project is on the cutting edge of a new technology whereby diagnosis, prognosis and optimal treatment strategy might be determined by analysis of circulating microRNAs. Dr. Tewari will optimize the isolation of exosomes and purification of microRNAs from prostate cancer models followed by genetic probing of these materials. This technology may ultimately be useful to patients for personalized treatment and improved prognostic information and is utterly original.
The Arnie's Army Creativity Award
Fred Hutchinson Cancer Research Center and University of Washington