Owen Witte, MD
About Owen Witte, MD
Target identification Combining In Vivo Tissue Transformation with Multi-parameter Profiling and “Surprisal Analysis”
The goal of this highly creative proposal is to search for and discover new pathways and therapeutic targets in advanced prostate cancer for therapeutic destruction of disease. A “first-in-field” mathematical modeling and statistical tool has been invented and will be used to discover gene expression patterns and protein modification events that correlate with disease progression yielding new pathways and targets. Findings from this mathematical analysis will be tested in human prostate tumors, as well as in mouse models of prostate cancer.
Potential patient benefit: Great progress has been made in development of new therapies for metastatic prostate cancer; however, the targets elucidated through this Creativity Award could provide an entirely new generation of medicines for metastatic prostate cancer.
The Ben Franklin-PCF Creativity Award
Distinguished Professor of Microbiology, Immunology, and Molecular Genetics
President's Chair in Developmental Immunology
David Geffen School of Medicine
University of California, Los Angeles