Pier Paolo Pandolfi, MD, PhD
About Pier Paolo Pandolfi, MD, PhD
Pro-Senescence Therapy for Cancer: A Novel Approach Towards Prostate Cancer Prevention and Cure—Identifying New Druggable Targets May Enable Scientists to Lull Prostate Cancer Cells to Sleep
Cellular senescence is a process whereby a cancer cell essentially “goes to sleep”. Dr. Pandolfi has discovered several druggable cellular signaling “nodes” that act together to cause a heretofore unknown form of senescence in prostate cancer cells. He believes that this process is also operative in the very difficult to eradicate cancer stem cell population. Chemical compounds against these targets that will drive prostate cancer cells into a state of senescence will be evaluated in specialized animal models of prostate cancer with the goal of clinical translation.
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Beth Israel Deaconess Medical Center