The 25th Annual Prostate Cancer Foundation Scientific Retreat was held at the La Costa Resort in Carlsbad, CA. on October 26 – 28, 2018. This event is the foremost scientific conference in the world on the biology and treatment of prostate cancer. The diversity, novelty, and extremely high impact of the topics presented as well as the diversity and excellence of the invited attendees make this a unique conference. The PCF Scientific Retreat reflects the unyielding commitment of PCF to ending death and suffering from prostate cancer. This investment by PCF fosters a collaborative culture unparalleled in any other cancer research area and has accelerated the understanding of prostate cancer biology and the treatment landscape.