The use of radioactive seed implantation after External Beam Radiation therapy has five-year disease-free rates around 50% (very similar to the success of salvage radiation therapy after surgery). Because this approach delivers radiation to very localized areas, it is not an optimal treatment for men with tumors that have spread beyond the prostate.

As with Brachytherapy used as a primary therapy, side effects tend to be less frequent and less severe compared with other therapies, such as salvage prostatectomy. However, some studies have found high rates of urinary Incontinence in men undergoing “salvage” brachytherapy, so careful consideration of existing urinary function and expected loss of function should be discussed fully with your doctors before any decision is made.