Challenge Award #1 Project Title:
Genomic signatures of response and resistance in advanced prostate cancer in American men of African ancestry
Project Overview:
Among Americans, African Americans (AA) experience prostate cancer twice as often and are 2.2 times more likely at risk for mortality when compared to European Americans (EA). An enhanced understanding of AA prostate cancer is a clear unmet need that will improve AA outcomes and close this persistent racial healthcare disparity. Dr. Mosquerra and team will be using state-of-the-art genomic analysis to unravel mutational signatures associated with African ancestry compared to EA men. By understanding biological variation between AA and EA prostate cancers, Dr. Mosquerra is poised to leverage these findings into novel approaches to treat AA men with or at risk for prostate cancer, helping close a crucial healthcare disparity.
Principle Investigators:
Additional Investigators:
Weill Cornell Medicine
Brian D. Robinson, MD
Columbia University Medicine
Charles G Drake
New York Genome Center Computational Biology
Nicolas Robine, PhD
New York Presbyterian Medicine
Jones Nauseef, MD, PhD
Challenge Award #2 Project Title:
Metabolic and Inflammatory Response to a Whole Food Plant-Based Diet in Overweight/Obese Men with Prostate Cancer Receiving Androgen Deprivation Therapy: A Phase II Randomized Study
Project Overview:
Obesity and androgen deprivation therapy (ADT) represent a clinical and metabolic state that negatively affects men with prostate cancer. Dr. Nanus and team will analyze a practical diet and behavior intervention that addresses the detrimental health effects of excess body fat and inflammation in prostate cancer patients on ADT. This first-in-field, comprehensive metabolic analysis will address a significant unmet need that could lead to improved outcomes and quality of life in prostate cancer patients undergoing ADT.
Principle Investigators:
John Hopkins University
Channing Paller, MD
Additional Investigators:
Weill Cornell Medicine
Katie Hootman, PhD
Jan Krumsiek, PhD
Karla Ballman, PhD
Columbia University Medical College
Mark Stein, MD
Hunter College, School of Urban Public Health
Victoria Fischer, PhD