Project Title:
Tissue-engineered model of bone metastasis for preclinical analysis and individualized medicine
Project Overview:
Prostate cancer has a high propensity to colonize bone, with many metastatic patients afflicted by skeletal lesions. Despite common therapy options prolonging overall survival, bone metastases are still lethal and are associated to poor patient outcomes. Dr. Dondossola will develop and characterize the bone mimetic environment (BME)’s ability to establish clinically relevant, patient-derived models of bone metastasis. This will allow identification of predictors of response and will support new precision medicine approaches to monitor and intervene with patients on an individual basis, improving the quality of life and survival of prostate cancer patients afflicted with bone metastases.
Principle Investigators:
Additional Investigators:
The University of Texas MD Anderson Cancer Center Pathology Anatomical Department
Michael Hwang, MD
Patricia Troncosso, MD
The University of Texas MD Cancer Center Genomic Medicine
Feng Wang, PhD
The University of Texas MD Anderson Cancer Center Genitourinary Medical Oncology
Paul G. Corn, MD, PhD
Nora M. Navone, MD, PhD
Fred Hutchinson Cancer Research Center Human Biology Division
Taran Gujral, PhD
Rice University Center for Engineering Complex Tissues
Antonios G Mikos, PhD