Project Title:
Therapeutic targeting of noncanonical Wnt signaling in advanced castration resistant prostate cancer
Project Overview:
The WNT pathway is a regulator of stem cells and fetal development that when altered, can drive cancer development and progression. Dr. McKay and team are developing a novel treatment for prostate cancer which targets the WNT pathway, and will test efficacy and mechanisms of action in a clinical trial, as well as establish biomarkers to identify which patients are most likely to benefit from this treatment.
Principle Investigators:
University of California, San Diego
Christina Jamieson, PhD
Additional Investigators:
University of California, San Diego
Justin Shaya, MD
J. Kellogg Parsons, MD, MPH
Pablo Tamayo, PhD
William Kim, PhD
Massachusetts General Hospital
David Miyamoto, MD, PhD