Challenge Award #1 Project Title:
Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis
Project Overview:
The mechanisms that underlie molecular changes in prostate cancer and promote aggressive phenotypes are currently not understood. Studies indicate that cytochrome c (Ctyc), a protein, is a vital component in the cell life or death decisions, allowing cancer cells to proliferate, metastasize, and evade treatment. Dr. Huettemann will investigate and characterize the role of Cytc acetylation in prostate cancer. The resulting improved diagnostic and prognostic tools can aide in new pharmacological interventions and improvement in patient well-being.
Principle Investigators:
Wayne State University Pharmacology
Izabella Podgorski, PhD
Additional Investigators:
Wayne State University Center for Molecular Medicine and Genetics
Junmei Wan, MD, MS
Challenge Award #2 Project Title:
High-intensity interval training and its impact on the quality of life, physical fitness and bone tumor microenvironment of men with metastatic prostate cancer
Project Overview:
There is an unmet need to devise and test behavioral interventions in an effort to improve patient outcomes among men with lethal prostate cancer. While studies have demonstrated that participation in regular exercise has consistently been shown to reduce cancer mortality and improve outcomes in cancer survivors, little is known about the systemic changes in a patient’s biochemistry. Dr. Beebe-Dimmer and team look to further develop the CAPABLE (CrossTraining and Physical Activity: A Better Life Experience) study in order to understand the program’s effect on a patient’s biochemistry and the resulting changes in the tumor microenvironment. Dr. Beebe-Dimmer’s trial has the potential to dramatically improve quality of life and physical fitness, as well as slow the progression of disease in men with metastatic prostate cancer.
Principle Investigators:
Wayne State University Pharmacology
Izabella Podgorski, PhD
Wayne State University Oncology
Elizabeth Heath, MD
Additional Investigators:
Wayne State University Oncology
Lance K Heilbrun, PhD
Alleda Mack, MD, PhD