About Franklin Huang
African-American men have higher incidence and death rates from prostate cancer compared to Caucasian men. Disease grade at presentation is more advanced and cancers are diagnosed at a younger age in African-American men.
The precise reason(s) for this disparity are generally unknown but might be related to various lifestyle, environmental, socioeconomic, and genomic factors.
Dr. Franklin Huang will systematically assess genomic alterations that occur in prostate cancers from African-American men and identify and characterize novel cancer-associated genes.
His preliminary studies have identified a novel putative tumor suppressor gene which is mutated in a subset of African-American patients, and these studies will evaluate the tumor suppressor functions of this gene.
If successful, this project will identify new therapeutic targets for prostate cancer in African-American men and expand the understanding of prostate cancer biology.
What this means for patients: African-American men have a higher risk for lethal prostate cancer. Characterizing the unique biology of prostate tumors in these patients will lead to discoveries of new therapies and improve patient outcome.
2014 Stewart Rahr-PCF Young Investigator
Franklin Huang, MD, PhD
Dana-Farber Cancer Institute
Levi Garraway, MD, PhD
Investigating the Genomics of African-American Prostate Cancer