Synergistic Targeting of AR and Androgen Metabolism in Prostate Cancer

About Synergistic Targeting of AR and Androgen Metabolism in Prostate Cancer

For advanced prostate cancer patients, the best available treatment is the removal of testosterone hormones (androgens) that drive the growth and progression of prostate cancer. Medications that reduce androgens cause clinical remission invariably followed by disease progression. It is now known that androgens can be produced in tumor tissue, which is one cause for disease progression. Drs. Balk, Kantoff and Nelson will carefully study androgen reduction in tumor tissue from patients treated with a new generation of androgen production inhibitors and determine the mechanism of inhibition. Since it is likely that patients will ultimately become resistant to the new medications, identification of the mechanism of resistance will help identify the next generation of prostate cancer treatments.
Research team members: Dr. Myles A. Brown, Dana-Farber Cancer Institute; Dr. Celestia Higano, University of Washington; Dr. Paul Lange, University of Washington; Dr. Bruce Montgomery, University of Washington; Dr. Elahe Mostaghel, Fred Hutchinson Cancer Center; Dr. Trevor M. Penning, University of Pennsylvania; Dr. Mary-Ellen Taplin, Dana-Farber Cancer Institute.

Lead Investigators:

Dr. Steven P. Balk, Beth Israel Deaconess Medical Center; Dr. Philip W. Kantoff, Dana-Farber Cancer Institute; Dr. Peter S. Nelson, Fred Hutchinson Cancer Research Center, University of Washington