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Certain oncogenic molecules in prostate cancer cells..
Theodoros Karantanos, MD:
MD Anderson Cancer Center
Mentors:
Timothy Thompson, PhD and Christopher Logothetis, MD
Project Title:
The role of aerobic glycolysis in the development of castrate resistant prostate cancer
T cells are a type of immune..
W. Nathaniel Brennen, PhD:
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Mentors:
John Isaacs, PhD, Charles Drake, MD, PhD
Proposal Title:
T cells Engineered to Selectively Deliver a PSA-activated Protoxin to Sites of Advanced Prostate Cancer
Dr. Armstrong earned a BS in Biomedical..
Andrew Armstrong, MD, ScM:
Duke University – Durham, NC
Preclinical assessment of mechanisms of resistance to..
Vivek Arora, MD, PhD:
Washington University
Mentor:
Charles Sawyers, MD
Project Title:
Defining strategies to overcome enzalutamide (Xtandi) resistance
Approximately 25% of patients who fail Xtandi..
Jennifer Bishop, PhD:
University of British Columbia
Mentors:
Martin Gleave, MD and Amina Zoubeidi, PhD
Project Title:
Regulation of cell plasticity by the androgen receptor: A novel mechanism of enzalutamide (Xtandi) resistance
The organization of DNA into super-structures is..
Irfan Asangani, PhD:
University of Michigan
Mentor:
Arul Chinnaiyan, MD, PhD
Project Title:
Characterization and therapeutic targeting of MMSET in prostate cancer
Engraftment of prostate cancer in bone heralds..
Charles Chan, PhD:
Stanford University School of Medicine
Mentors:
Irving Weissman, MD and Michael Longaker, MD
Project Title:
Identification and therapeutic targeting of cancer stem cell niche interactions in metastatic prostate bone marrow disease
An unmet medical need is the control..
Chia-Yi Chu, PhD:
Cedars-Sinai Medical Center
Mentor:
Leland Chung, PhD
Project Title:
Metastasis-initiating cells (MICs) as predictors of lethal progression of human prostate cancer
Molecular imaging of prostate cancer to determine..
Michael Evans, PhD:
University of California, San Francisco
Mentors:
Charles Sawyers, MD and Jason Lewis, PhD
Project Title:
Exploiting the genetics of advanced prostate cancer for tumor detection and therapy with transferrin-based radionuclides
Jason A. Efstathiou, MD, DPhil:
Massachusetts General Hospital
Mentor:
Matthew R. Smith, MD, PhD
Project Title:
Predictors of Response and Failure to Radiotherapy for Prostate Cancer in a Randomized Trial
Proteomics is the study of proteins in..
Geraldine Gueron, PhD:
Iquibicen-Conicet (Argentina)
Mentor:
Elba Vazquez, PhD
Project Title:
Proteome-base biomarkers in prostate cancer: protein profiling using mass spectrometry, bioinformatics based approach and tissue microarray technology
Immunotherapy has come of age with the..
Mentors:
Philip Kantoff, MD and Christopher Sweeney, MBBS
Project Title:
Clinical exploration of innovative targeted and immune modulating therapies in prostate cancer
Understanding resistance to new treatments for advanced,..
Emmanuel Antonarakis, MD:
Johns Hopkins University School of Medicine
Mentors:
Michael Carducci, MD and Jun Luo, PhD
Project Title:
Understanding mechanisms of response and resistance to abiraterone (Zytiga) and enzalutamide (Xtandi) in men with metastatic castration-resistant prostate cancer, by interrogation of tumor biopsies for androgen receptor splice variants.
Over 1 million prostate biopsies are performed..
Syed Adnan Ali, MD:
Mount Sinai School of Medicine
Mentor:
Ashutosh Tewari, MD
Project Title:
Intratumor Heterogeneity (ITH) in Prostate Cancer
Long non-coding RNAs (lncRNAs) such as PCAT1..
Institution:
University of Michigan
Mentors:
Arul Chinnaiyan, MD, PhD; Felix Feng, MD
Proposal Title:
Investigating Long Noncoding RNAs in Aggressive Prostate Cancer
Next generation sequencing (NGS) is a growing..
Rendong Yang, PhD:
University of Minnesota
Mentor:
Scott Dehm, PhD
Proposal Title:
Delineating Coding and Regulatory Indels in Prostate Cancer
Genomic analysis of cancer tissue has enabled..
Adam Sowalsky, PhD:
National Cancer Institute
Mentors:
Kathleen Kelly, PhD; William Dahut, MD
Proposal Title:
Investigations into the Mechanisms of Resistance to Enzalutamide in CRPC
As life expectancy rises, greater numbers of..
Prasanna Sooriakumaran, MBBS, PhD:
University of Oxford
Mentor:
Freddie C. Hamdy, MD
Proposal Title:
Improving Quality of Care for Men with Skeletal Metastases from Prostate Cancer: Defining the Burden-of-Treatment and its Management, and Developing Models to Predict Quality-of-Life
Cancer is characterized by accumulation and loss..
Shabnam Shalapour, PhD:
University of California, San Diego
Mentor:
Michael Karin, PhD
Proposal Title:
Development of Immunosuppressive Plasmocytes that Interfere with T-Cell-Dependent Immunogenic Chemotherapy in Prostate Cancer
Supplementing a patient’s immune response by engineering..
Saul Priceman, PhD:
City of Hope National Medical Center
Mentor:
Stephen Forman, MD
Proposal Title:
Targeting Metastatic Prostate Cancer with PSA-Specific Chimeric Antigen Receptor-Engineered T-Cells
New hormonal treatments for prostate cancer such..
Sean McGuire, MD, PhD:
Baylor College of Medicine
Mentor:
Bert O’Malley, MD
Proposal Title:
Targeting the Mitochondrial Pyruvate Carrier in Castration- Resistant Prostate Cancer
Immune checkpoint inhibitors “take the brakes” off..
Ravi Madan, MD:
National Cancer Institute
Mentor:
James Gulley, MD, PhD
Proposal Title:
Using A Therapeutic Cancer Vaccine to Enhance Anti-PD-1 Therapy Prior to Prostatectomy
While most men with prostate cancer initially..
Zhenfei Li, PhD:
Cleveland Clinic Foundation
Mentors:
Nima Sharifi, MD; Eric Klein, MD
Proposal Title:
A Novel Abiraterone Metabolite as a Predictive Biomarker for Clinical Response to Abiraterone
A highly aggressive subtype of treatment-resistant prostate..
John Kyung Lee, MD:
University of Washington
Mentor:
Owen Witte, MD
Proposal Title:
Therapeutic Targeting of N-Myc-Driven Human Small Cell Neuroendocrine Prostate Cancer
New therapeutic targets and prognostic biomarkers for..
Vishal Kothari, PhD:
University of Michigan
Mentors:
Arul Chinnaiyan, MD, PhD; Felix Feng, MD
Proposal Title:
Investigating DNAPK as a Therapeutic Target and a Prognostic Biomarker in Castration-Resistant Prostate Cancer
The emergence of treatment-resistant prostate cancer (CRPC)..
Won Kim, MD:
University of California, San Francisco
Mentors:
Charles Ryan, MD; Eric Small, MD
Proposal Title:
Dissecting Variant Androgen Signaling Phenotypes to Guide Treatment Selection in Abiraterone Acetate and Enzalutamide-Resistant Prostate Cancer
Metabolic oxidative phosphorylation (OXPHOS) is a biochemical..
Joseph Ippolito, MD, PhD:
Washington University School of Medicine in St. Louis
Mentors:
Jeffrey Arbeit, MD; Farrokh Dehdashti, MD
Proposal Title:
Characterizing and Imaging Metabolic Symbiosis in Castrate- Resistant Prostate Cancer
Cell signaling in cancer causes uncontrolled cell..
Howard Scher, MD –:
Memorial Sloan-Kettering Cancer Center
Development of Combined Inhibition of AR and PI3K Signaling as a Therapeutic Strategy for Advanced Prostate Cancer
Co-Investigators:
Charles Sawyers, MD; Brett Carver, MD; Neal Rosen, MD, PhD
Long noncoding RNAs (lncRNAs) play a critical..
Amanda Hargrove, PhD:
Duke University
Mentors:
Hashim Al-Hashimi, PhD; Peter Dervan, PhD
Proposal Title:
Targeting the lncRNA SChLAP1 in Aggressive Prostate Cancer by the Assembly of Multivalent Small Molecule Inhibitor
Men with progressive metastatic prostate cancer are..
Justin Drake, PhD:
Rutgers University Cancer Institute of New Jersey
Mentor:
Robert DiPaola, MD
Proposal Title:
Elucidating Kinase Activation Pathways in Advanced Prostate Cancer
Dr. Sanda and his cross-disciplinary team of..
Martin Sanda, MD –:
Beth Israel Deaconess Medical Center
Nanoparticle-Targeted Peptide Vaccines for Prostate Cancer: The Harvard – Hopkins – Carolina Consortium
Co-Investigators:
Joseph M DeSimone, PhD; Simon M Arredouani, PhD; Charles Drake, MD, PhD
One of the causes for the initiation..
William G. Nelson, MD, PhD – :
Johns Hopkins Medicine
Induction of Synthetic Lethality with Epigenetic therapy (ISLET) for Systemic Treatment of Prostate Cancer
Co-Investigators:
Srinivasan Yegnasubramanian, MD, PhD; Jun O. Liu, PhD; Stephen B. Baylin, MD; Michael A. Carducci, MD; Martin J. Aryee, PhD
Despite initial response, most prostate cancers will..
Christopher J. Logothetis, MD –:
The University of Texas MD Anderson Cancer Center Mechanisms of Resistance to Androgen Biosynthesis Inhibition in Castration-Resistant Prostate Cancer Bone Metastases
Co-Investigators:
Gary Gallick, PhD; Sankar Maity, PhD; Randall Millikan, MD, PhD; Mark Bedford, PhD; Eleni Efstathiou, MD, PhD
Although family history is well-established as a..
Heather Cheng, MD, PhD:
University of Washington
Mentor:
Peter Nelson, MD
Proposal Title:
Identifying High-Penetrance Prostate Cancer Risk Genes: Leveraging Families for Next Generation Discovery and Prevention
As prostate cancer advances and spreads, it..
Dr. Glenn Liu, MD –:
UW Carbone Cancer Center Imaging Biomarkers of Treatment Response Using NaF PET/CT Imaging: a Prostate Cancer Clinical Trials Consortium (PCCTC) Effort
Co-Investigators:
Michael Morris; William Dahut, MD; Steven Larson, MD; Peter Choyke, MD; Robert Jeraj, PhD